Do you have such friends around you? They may feel dry eyes and want to cry, and may also have dry mouth, swollen parotid glands, and many cavities and other symptoms. If so, they may be suffering from dry syndrome. Dry syndrome is a chronic autoimmune disease characterized by reduced tear and saliva production. It is mostly seen with women aged 45-55. Common manifestations include dry mouth and eyes, swollen parotid glands, rampant dental caries and systemic damage, which can be divided into primary dry syndrome and secondary dry syndrome. Secondary dry syndrome is often associated with rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis and other rheumatic diseases. The etiology of dry syndrome is still unclear and may be related to genetics, immunity, viral infections, and sex hormone levels. Patients have family aggregation, the presence of a variety of autoantibodies and a large number of immunoglobulins and immune complexes in the body, the incidence of women is significantly higher than that of men. 1. Dry mouth: Due to the reduction of saliva secretion, patients often feel dry mouth, dry and cracked tongue, chewing and swallowing difficulties. In severe cases, they need to drink water frequently when speaking, and when eating solid food, they need to accompany water or liquid food to send down, and sometimes they need to get up at night to drink water. Due to the proliferation of bacteria in the mouth, bad breath, tooth decay followed by flake loss, and gum recession can occur. About half of the patients may have mumps, which is characterized by alternating painful swelling of the parotid glands, which may subside on its own in about 10 days, and sometimes may remain enlarged. 2. Dry eyes: Patients may also have dry eyes, foreign body sensation, burning sensation, and few tears due to reduced lacrimal gland secretion of mucin, and in severe cases, painful crying without tears. 3.Dryness of other parts: other superficial parts such as skin, nasal mucosa, digestive tract mucosa and vaginal mucosa can be dry due to the reduction of glandular secretion and corresponding parts. In the early stage, the skin can be normal, but as the disease progresses, the secretion of sweat glands can be affected, and sweating can be reduced or even absent. Female patients can also have vaginal dryness, burning sensation and vulvar atrophy. In addition to dryness of the mouth and eyes, patients may also have systemic symptoms such as fatigue and fever, etc. About 2/3 of patients may have systemic damage. (1) Skin, muscle and joint involvement: skin manifests as vasculitis, such as allergic purpura-like rash, mostly in the lower extremities, red papules with clear borders of the size of a grain of rice, do not fade when pressed, appear in batches, and last about 10 days to fade on their own. Patients may have myalgia and non-deforming arthritis or arthralgia. (2) Respiratory involvement: Respiratory tract damage is caused by lymphocytic infiltration of the upper and lower respiratory tract mucosa and atrophy of its exocrine glands. About 25% of patients have dry cough in the trachea and bronchi due to dryness, recurrent bronchitis and pulmonary atelectasis, most commonly manifested by interstitial pneumonia and interstitial fibrosis of the lungs with cough and dyspnea. (3) Renal involvement About 30% -50% of patients have renal damage Subclinical renal tubular acidosis, type Ι renal tubular acidosis and glomerulonephritis may occur, and even renal failure may occur. Among them, distal tubular damage is most common, with increased urinary pH, urinary concentration dysfunction, nephrogenic uremia, renal chondromalacia, urinary stones and calcification of renal tissue, and hypokalemic muscle paralysis. (4) Digestive system involvement: About 63%-70% of patients have atrophic gastritis, which manifests as epigastric discomfort, nausea, abdominal distension, etc. About 25% of patients may have hepatomegaly and increased transaminases, which may be accompanied by primary biliary cirrhosis or autoimmune hepatitis. (5) Neurological involvement About 8.3%-32% of patients show lower limb numbness, peripheral sensory disorders, carpal tunnel syndrome, low tendon reflexes, etc. About 5% of patients show epileptic-like seizures, various psychiatric symptoms and disorders of consciousness, focal symptoms, etc. (6) Hematologic involvement Decrease in white blood cells, hemoglobin and platelets may occur Patients with significant decrease in platelets may have bleeding tendency. The incidence of lymphoma in patients with this disease is about 44 times higher than normal, and may be combined with non-Hodgkin’s lymphoma and multiple myeloma. If the above symptoms appear, please go to the rheumatology department in time to further improve the relevant serum immunological examination, oral or ophthalmic examination to confirm whether it is dry syndrome. Once diagnosed, treatment should be standardized. The course of this disease is slow and the prognosis is relatively good, and most of the disease can be controlled to achieve remission after proper treatment. If patients have systemic damage, especially progressive pulmonary fibrosis, central neuropathy, glomerular damage with renal insufficiency and malignant lymphoma, the prognosis is poor, so it is important to seek medical treatment as early as possible to control the disease in the cradle.