The symptoms of advanced diabetic nephropathy mainly cover the following aspects: 1, proteinuria: there is only a trace amount of albumin leakage in the urine in the early stage of diabetic nephropathy, but with the further development of the lesion, the urinary protein gradually increases and becomes persistent proteinuria, and the severity of the urinary protein is mostly progressive until the emergence of nephrotic syndrome; 2, edema: there is no swelling in most of the early diabetic nephropathy patients, and a few patients may have mild edema before the decrease of plasma A few patients may have mild edema before the decrease of plasma albumin, and edema will appear when the quantitative amount of 24-hour urinary protein is more than 3g; 3. Hypertension: Hypertension is very common in patients with diabetic nephropathy, and severe nephropathy is often combined with hypertension, which can aggravate the progress and deterioration of diabetic nephropathy, so effective control of hypertension is very important for patients with diabetic nephropathy; 4. Renal insufficiency: once diabetic nephropathy begins, its process is mostly in the development of diabetic nephropathy until the emergence of nephrotic syndrome. Once diabetic nephropathy begins, the process is progressive, azotemia, uremia is its ultimate end; 5, anemia: diabetic patients with renal insufficiency, there can be mild to moderate anemia, with iron treatment is ineffective, the type of anemia is mostly due to erythropoietin deficiency. 6, other symptoms: diabetic retinopathy is not a nephrotic lesion, but it is often concurrently present with diabetic nephropathy.