If the pregnant man carries hepatitis B, if the pregnant woman has hepatitis B antibody, then the baby can be vaccinated normally with hepatitis B vaccine without the use of hepatitis B immunoglobulin; if the pregnant woman is negative for hepatitis B antibody, the newborn is better to be injected with 1 injection of hepatitis B immunoglobulin in addition to hepatitis B vaccine for hepatitis B blocking treatment. According to the Clinical Guidelines for the Prevention of Mother-to-Child Transmission of Hepatitis B Virus, it is recommended that if the father of the newborn is HBsAg-positive, he needs to pay attention to the prevention of Hepatitis B transmission when he is in close contact because of caring for the newborn. If the pregnant woman is positive for Hepatitis B surface antibody, then the pregnant woman can give her child the antibody, which will have a passive immunization effect, and normal vaccination against Hepatitis B will be sufficient, without the use of Hepatitis B immunoglobulin. If the pregnant woman is negative for Hepatitis B surface antibody, most newborns need about 1 week after the 2nd Hepatitis B vaccination to produce antibody, and are susceptible to Hepatitis B until then. If the father is HBsAg-positive, especially HBeAg-positive, he needs to avoid close contact with the baby, and it is best for the newborn to receive one injection of Hepatitis B Immune Globulin for Hepatitis B blockade. In addition, if a pregnant woman is negative for hepatitis B surface antibody, hepatitis B vaccination is also recommended after breastfeeding to avoid hepatitis B virus infection. According to the current immunization regulations in China, babies will be vaccinated against hepatitis B from 0-1-6 months. Whether it is still necessary for babies to be vaccinated with hepatitis B immunoglobulin to block hepatitis B treatment needs to be considered in the context of the pregnant woman’s condition, and it is recommended that she consult with her obstetrician for evaluation.