An overdose may, in general, result in the following common reactions I. Gastrointestinal reactions, which may manifest as nausea, vomiting, abdominal pain, abdominal distension and other manifestations. It is mainly an overdose of the drug, which acts as a strong stimulus to the gastrointestinal tract, causing reflex vomiting of gastrointestinal function. Second, skin allergy, can be manifested as widespread or scattered papule-like changes in the skin. Accompanied by redness, swelling, itching and other symptoms, more common for patients with chronic skin disease. Third, neurological symptoms such as coma, patients who take an overdose of sleeping pills can paralyze the nervous system. This causes loss of consciousness and coma in patients. Fourth, drug-related liver injury can be manifested as yellow staining of the skin and sclera, deep yellow color of urine, and painful knocking in the liver area. This is because drugs are detoxified and metabolized by the liver. Taking a large amount of drugs increases the burden on the liver and causes drug-related liver injury.