Symptoms of stage III syphilis are characterized by nodular syphilis rash, gumma, and other manifestations such as bone syphilis and cardiovascular syphilis. 1. Nodular syphilis rash: the lesions are clustered copper-red infiltrating nodules with flaking or necrotic ulcers on the surface, which occur on the head, face, shoulders, back and extensor sides of the limbs. 2. Gum swelling: belongs to one of the signature lesions of this stage, preferably occurring in the lower legs, followed by bones, oral cavity, mucous membrane of the upper respiratory tract and internal organs. The lesions appear as horseshoe-shaped ulcers with elevated margins and a sticky, gummy secretion on the surface. If the oral mucosa is damaged, it may cause dysphagia or dysphagia. 3. Bone syphilis: common in long bone tympanitis, patients will have bone pain, periosteal hyperplasia and other symptoms. In severe cases, it may cause bone perforation, joint deformity or pathologic fracture. 4. Cardiovascular syphilis: most commonly seen in syphilitic aortitis, aortic valve insufficiency, coronary artery stenosis, aortic aneurysm and so on. Stage III syphilis may also have other symptoms, it is recommended that patients with stage III syphilis actively cooperate with the doctor to carry out a series of standardized examination, treatment, control of the condition, and strengthen the management of daily life, so as not to delay the condition.