Bladder perfusion is a very important therapeutic means for treating bladder cancer. The drugs used in bladder perfusion mainly include anti-tumor antibiotics, such as epirubicin, gemcitabine, mitomycin, BCG and so on, which will produce inflammation in the bladder locally after being perfused to the local area of the bladder through catheter and kill the cancerous cells through the inflammation, so that there will be localized pain and discomfort in the time of bladder perfusion. Of course, certain drugs, such as hormone, saline or even surface anesthesia drug Lidocaine, will be added during bladder instillation, which will reduce the local stimulation of bladder mucosa caused by the instilled chemical drugs, and thus reduce the pain. In short, the pain of bladder instillation can still be tolerated.