The best time to take aspirin is recommended to be at night before bedtime or around ten o’clock. This is because after dinner to ten o’clock, the patient’s food has basically been digested and absorbed, the stomach emptied, taking the drug will not affect the absorption and utilization of the drug, and the night will be in a fasting state, until the next morning when eating breakfast will have food intake again, more conducive to the drug to work better. However, aspirin has a certain stimulating effect on the gastrointestinal tract, especially it will promote the secretion of gastric acid, so if the patient has a long fasting time at night and the secretion of gastric acid is high, it may cause stomach discomfort and even induce gastric ulcers or duodenal ulcers. If the patient cannot tolerate this way of taking the medicine, it is still recommended to take it in the morning, which is half an hour before or after a meal, which can reduce the stimulation of the gastrointestinal tract.