First, the epidemiological status of obesity International authority on weight management experts, the nation’s best doctors Dr. Jamie pointed out that today 40% of Chinese people tend to be obese, the number of more than 200 million people, especially young people and children obesity increased significantly. There are many diseases caused by obesity or related to obesity, some tumors (breast, colon and endometrium), and these tumors have become the main cause of death. The cause of obesity is a “hundred gardens”, affected by many factors, mainly eating fat, too much energy, and physical activity is too little, the remaining energy in the form of fat stored in the body, to a certain extent when the formation of overweight M obesity; in addition, but also with the genetic, psychosocial, neuroendocrine factors, etc. WHO formally announced to the world: “Obesity is the most common disease in the world. WHO officially announced to the world: “Obesity has become the world’s primary health problem”, “Now the awareness of the relationship between obesity and diabetes or heart disease has grown, but the relationship between obesity and cancer has not been well attended to. Wang Hebing, Department of Breast Surgery, First Hospital of Sanming City, China Breast diseases and chronic diseases Breast diseases (breast nodules, breast cysts, breast fibroids, breast cancer, excluding breast hyperplasia) are currently considered to be a chronic disease, the onset of chronic diseases is a “gradual” process, there are initiation of risk factors, such as irrational diet, lack of exercise, There are initiating risk factors, such as irrational diet, lack of exercise, poor tobacco and alcohol habits, etc.; there are also intermediate disease-causing risk factors, such as overweight/obesity, which are independent and important risk factors for chronic diseases. In order to cope with the challenge of chronic diseases, the key is to improve the lifestyle of the residents: that is, to encourage a reasonable combination of meals, consistent exercise, to achieve a balance between food and movement, to adhere to the smoking cessation and alcohol limitations do not rebound, and to have a good mood every day, etc. are the fundamental measures to prevent and control the effectiveness of chronic diseases. In addition, a good annual health checkup, timely detection of disease-causing risk factors, and actively take preventive measures, on the one hand, help to reduce the occurrence of chronic diseases, and on the other hand, can improve the level of health and create a high quality of life. The high detection rate of breast diseases, on the one hand, may be related to the endocrine disorders caused by the accelerated pace of modernized life, fierce social competition, and the increased pressure of women’s work and life; on the other hand, the serious pollution of the environment and the increase of hormone content in food have spawned the occurrence of breast diseases, affecting women’s physical and mental health. 2007, the Ministry of Health formally announced that breast cancer is the most common incidence of malignant tumors among women in China, and it is important to strengthen screening, prevention, and screening of benign lesions of the breast. Strengthening the screening, follow-up and tracking of benign breast lesions is of great significance in improving the diagnosis rate of early breast cancer. Obesity and the occurrence of breast cancer Obesity is a particularly important lifestyle-related cancer determinant, including colon cancer, breast cancer, kidney cancer, including six types of cancer, have been confirmed to be related to obesity. In general, obesity increases the risk of breast cancer in postmenopausal women. New findings suggest that this may be related to the inhibition of p53 by prostaglandin E2, which down-regulates aromatase expression. However, there are fewer studies on premenopausal women, and there is no unified conclusion. Most scholars believe that obesity is a protective factor for breast cancer, but it may or may not affect the risk of breast cancer. Obesity and Prognosis of Breast Cancer The result of a retrospective cohort study shows that for early breast cancer patients, obesity can increase the death rate related to breast cancer. It can be seen that obesity can lead to poor prognosis of breast cancer, which may have the following reasons. First, obesity can increase the incidence of cardiovascular disease, other tumors (e.g. colorectal cancer, endometrial cancer, pancreatic cancer) and other diseases. Undoubtedly, these complications are bound to affect the prognosis of breast cancer patients by increasing their all-cause mortality. Secondly, obesity also affects the response of breast cancer patients to treatment, especially to chemotherapy. V. Possible mechanisms of obesity leading to breast cancer Obese individuals have different expression levels of relevant adipokines such as leptin and lipocalin due to their increased adipose tissue. Leptin is a product encoded by the obesity gene and is mainly produced by adipocytes. Similar to insulin, obese individuals also have hyperleptinemia and leptin resistance. High levels of leptin promote peripheral aromatase action and increase estradiol production, thereby promoting tumor formation in breast epithelial cells. Leptin can also directly upregulate IGF-1R levels. The binding of IGF-1R to IGF is particularly important for the initiation of various intracellular signaling pathways, including Akt signaling; this promotes cell growth, proliferation, and inhibits apoptosis. In contrast to leptin, lipocalin is reduced in obese and diabetic populations, and it is considered to be a protective factor against breast cancer, which is mainly realized through the regulation of Ras-MAPK and PI3K-Akt signaling pathways, apoptosis, and inhibition of the aromatization process. Obesity and Breast Cancer Prevention and Treatment Lifestyle change through dietary regulation and moderate exercise is the most important way of obesity-related breast cancer prevention and treatment. The American Cancer Society has formulated nutrition and exercise guidelines specifically for cancer survivors. Dietary regulation mainly includes limiting the amount of red meat, increasing the intake of vegetables and fruits, and choosing whole grains instead of refined grains, etc. In terms of exercise, it includes weekly physical exercise of 150 min and strength training of at least 2 d per week. Losing 6% to 7% of body weight through diet or exercise improves patients’ quality of life and makes them feel better about themselves in terms of their health status. The effect of exercise was more pronounced than diet when comparing exercise alone with diet alone. Physical activity not only reduces the risk of breast cancer recurrence and the associated morbidity and mortality, but also mitigates treatment-related adverse effects and improves patients’ quality of life. However, most patients not only do not achieve the recommended amount of exercise, but also their sedentary time is even more than normal. Therefore, it is essential to enhance patients’ awareness of the importance of lifestyle intervention, especially moderate exercise. Warm tips: With the change of economic level and lifestyle, the relationship between obesity and breast cancer incidence has been increasing in China, and this relationship is getting more and more attention. Obesity can affect the occurrence, recurrence and metastasis of breast cancer, and lead to a poor prognosis of breast cancer. This may be associated with elevated insulin and IGF-1 and their receptors, adipokines and inflammatory mediators. However, this relationship and its associated mechanisms need to be confirmed by more research findings. Recognizing the intrinsic relationship between obesity and breast cancer could provide help in developing new strategies for the prevention and treatment of breast cancer. According to a report by Cancer Research UK and the UK Health Forum, by 2035 it is expected that 72% of adults in the UK will be overweight or obese if changes are not made, which will result in almost 670,000 extra people with cancer, as well as several million more people with diabetes and heart disease. This report, although specific to the UK, is enough to get our attention. Obesity and breast cancer have a close relationship, control weight gain, to prevent the occurrence of female breast cancer has a certain role. Weight control, scientific diet, away from breast disease is not a dream.