81 years old with advanced lung cancer taking targeted drugs can usually be tolerated. Targeted drugs for lung cancer are different according to the mutated genes. Targeted drugs for lung cancer include gefitinib, afatinib, ositinib, loratinib and so on. These drugs have less side effects compared with chemotherapy and are relatively safe. Patients can generally tolerate them. The side effects of targeted drugs for lung cancer generally include gastrointestinal reaction, bone marrow suppression, impaired liver and kidney function, dizziness, hypertension, etc. However, the symptoms are generally mild, and patients can generally tolerate them, and many of the side effects may be reduced or disappeared with the prolongation of the time of taking targeted drugs. Patients with advanced lung cancer at the age of 81 should go to the hospital in time and be given treatment under the guidance of oncologists to improve their prognosis.