Tobramycin is not recommended for use during pregnancy, pregnant women have been used, it is recommended to monitor the situation after use, regularly improve the prenatal examination to assess fetal development, according to the doctor’s assessment of the treatment. Tobramycin dosage form mainly contains eye drops and ophthalmic ointment, often used in combination, with similar indications, contraindications, etc. It is mainly used for local anti-infective treatment of sensitive bacterial infections of the external eye and appendages, and the adverse reactions are mainly eye allergy, eye itching, eyelid edema, eye congestion, increased tearing, etc. It is contraindicated in persons who have allergy to the drug as well as those who are allergic to aminoglycoside drugs. Due to the limited data on the drug during pregnancy, the use of tobramycin is not recommended during pregnancy, and pregnant women who have already used tobramycin are advised to monitor for any discomfort after use, complete the prenatal checkup evaluation as scheduled, and perform according to the obstetrician’s recommendations. There are more contraindications to the use of drugs during pregnancy, it is recommended to use the drug with caution during pregnancy and consult your doctor in detail before use.