Treatment of HFMD includes general treatment (diet, etc.) and drug treatment (antipyretic drugs, antiviral drugs, glucocorticoids and gammaglobulin, etc.). HFMD is common in children under 5 years old. The main clinical manifestations are fever, many herpes appearing in children’s mouth, hands and feet, and some children will show symptoms of neurological involvement such as poor spirit, headache, vomiting, or symptoms such as accelerated heart rate, accelerated respiration, shortness of breath, and cyanosis (purplish-black color of the lips and mouth area) when they enter into the neurological involvement stage and the stage of cardiorespiratory failure. 1. General treatment, after infected with HFMD, good oral and skin care. Clothes used by the affected children should be fully sterilized and the home should be ventilated frequently. Don’t eat cold food and raw water. Dietary advice is to eat easy-to-digest and non-irritating food. 2. Medication, the cause of HFMD is coxsackievirus infection, but there is no specific antiviral drug, you can use broad-spectrum antiviral drugs, such as ribavirin under the guidance of a physician. For the emergence of high fever, such as body temperature higher than 38.5 ℃, can take antipyretic drugs; the emergence of convulsions of cases need to stop the alarm in a timely manner, commonly used drugs such as midazolam, diazepam, the need for close monitoring of vital signs, ready to do respiratory support. Some severe cases may have cerebral edema, cardio-pulmonary edema, shock, high cranial pressure and other symptoms, need to be hospitalized, and give the appropriate dehydration drugs, drugs to reduce cranial pressure or vasoactive drugs. Glucocorticoids and gammaglobulin may be used in cases of encephalomyelitis and persistent high fever. All of the above drugs should be used under the guidance of a physician, and should not be used on their own. There are many ways of spreading HFMD, prevention is the key, in our daily life we have to develop good hygiene habits and healthy eating habits. Children with HFMD need to be seen by a physician in a timely manner.