The probability of sequelae of neonatal hypoxic-ischemic encephalopathy is about 20%~30%, and its prognosis is related to Apgar score and severity of the disease. The incidence of neonatal hypoxic-ischemic encephalopathy in China is 3‰~6‰, of which 15%~20% die in the neonatal period. About 20%~30% of the survivors may be left with different degrees of neurological sequelae, such as motor or intellectual developmental disorders, cerebral palsy, epilepsy and so on. The prognosis is related to the Apgar score, severity of the disease, and whether the resuscitation is correct and timely, etc. Survivors with Apgar scores less than or equal to 3 and persisting for 15 minutes or more, convulsions, impaired consciousness, brainstem symptoms lasting more than 1 week, and persistent abnormalities on electroencephalogram (EEG) have a high mortality rate, and the survivors often suffer from sequelae of varying severity. Early rehabilitation is recommended after stabilization.