Whether neonatal hypoxic-ischemic encephalopathy can be cured depends on the extent of the disease, the timing of treatment, and one’s own situation, and there are big differences between individuals. Some of them can be controlled by active treatment, while some of them may have different degrees of neurological sequelae. Neonatal hypoxic-ischemic encephalopathy is mainly caused by perinatal asphyxia, which leads to hypoxia and ischemia resulting in brain damage. Typical clinical manifestations include impaired consciousness, abnormal muscle tone, abnormal primitive reflexes, and elevated intracranial pressure. Acute phase treatment centers on different modalities of oxygen therapy, such as hyperbaric oxygen therapy and artificial ventilation, in order to maintain good ventilation and hyperventilation. Secondly, symptomatic treatment, such as the use of furosemide, mannitol and other drugs to reduce blood pressure when intracranial pressure is elevated as prescribed by the doctor. It can also be treated with sub-low temperature, which can protect brain cells. After active treatment, most of the disease can be controlled to improve the symptoms, but some of them may have sequelae such as movement disorders, intellectual disabilities, etc. Whether the disease can be cured depends on the condition, and it is recommended to be determined after evaluation by a specialist.