Typically, gastric sinusitis leads to moderate heterotrophic hyperplasia. The gastric sinus refers to the junction of the body of the stomach and the duodenum. Gastric sinusitis is an inflammation of the mucosa that occurs in the area of the gastric sinus and is associated with factors such as Helicobacter pylori infection, smoking, alcohol consumption, and severe trauma. It can manifest as epigastric fullness and discomfort and chronic mid-upper abdominal pain, often with periodic episodes, which can be accompanied by belching (hiccups), loss of appetite, diarrhea, constipation, anemia, and so on. Heteroplasia is a proliferative change associated with tumors that can occur anywhere in the body, such as the stomach and intestines. Moderate heterotrophic hyperplasia, also known as grade II intraepithelial neoplasia, is a precancerous lesion that is not cancerous, but has a chance of transforming into cancer. Gastric sinusitis can change from inflammation to precancerous lesions such as intermediate heterozygous hyperplasia under the stimulation of alcohol, smoking, and bad dietary habits such as spicy stimulation and greasy food such as spicy hot pot, fried chicken, and so on. It is recommended that patients seek timely medical attention to clarify the diagnosis, under the guidance of the doctor for targeted treatment.