Mesangial proliferative nephritis is a relatively common type of pathology, and its treatment is mainly based on specific clinical symptoms and protein quantification. For patients with relatively mild clinical manifestations, as well as relatively small urine protein quantification, they can be treated simply by applying ACEI or ARB drugs, and the more commonly used drugs include Irbesartan, Valsartan, Benadryl, and so on. If you reach the level of nephrotic syndrome, 24-hour urine protein quantitative more than 3.5g, albumin less than 30g / L, you need to add hormone therapy, the more commonly used program is the full amount of prednisone treatment, regular review of relevant indicators, regular hormone dose reduction, to prevent the recurrence of the disease. For the more special type, that is, IgA nephropathy, which also manifests as mesangial proliferative nephritis, its treatment goal is to require 24-hour urine protein quantitatively less than 0.5g, and the blood pressure is controlled to be less than 130/80mmHg, so that the deterioration of renal function can be stopped.