Whether to breastfeed or not to breastfeed a baby when the mother is infected with Hepatitis B virus remains a major issue in the eyes of many members of the public. The reason given for not breastfeeding is that breast milk carries the hepatitis B virus, which can be passed on to the baby. Theoretically, hepatitis B virus may be transmitted through breastfeeding, but this has not yet been proven, and fecal-oral transmission of hepatitis B virus has been disproved by animal experiments. At present, all the domestic and foreign clinical guidelines on hepatitis B proposed in the transmission of hepatitis B include the following routes: 1, mother-to-child vertical transmission; 2, sexual intercourse; 3, sharing drug injection equipment; 4, sharing razors and toothbrushes and other daily objects; 5, open wounds to the direct contact of infected virus body fluids. Research statistics show that there is no significant difference in the transmission rate of hepatitis B virus between bottle-feeding and breast-feeding; on the contrary, the clearance rate of hepatitis B virus is higher in breast-feeding than in bottle-feeding. Moreover, after the implementation of hepatitis B vaccine and highly effective hepatitis B immunoglobulin prophylaxis after birth, children can basically avoid hepatitis B virus infection through breastfeeding. For this reason, hepatitis B experts advocate that hepatitis B-infected mothers should be able to breastfeed their babies themselves. Mothers with hepatitis B should not be denied the right to breastfeed their babies, after all, breast milk is the best gift a mother can give her baby! However, if there is bleeding and ulcers on the nipple, breastfeeding is not advisable. Children with ulcers or wounds in the mouth, also suspend breastfeeding, because the blood or tissue at the ulcers have been infected by the hepatitis B virus, which can easily enter the body of the child through the oral injuries; before breastfeeding should be disinfected their own hands, to minimize the chances of contagion. Regular and timely administration of highly effective hepatitis B immunoglobulin at the time of birth and timely vaccination against hepatitis B are the scientific ways to prevent hepatitis B infection in babies of hepatitis B mothers.