Intestinalization is the pathological term, and moderate is the degree of intestinalization. Some require biopsy during gastroscopy, and the pathological changes are inflammation, enterosis, and abnormal hyperplasia. The degree of intestinalization is classified as mild, moderate or severe. Severe enterosis is a precancerous lesion and should be treated actively. Moderate intestinalization should also be reviewed regularly and needs to be actively managed if there is aggravation.
There is a relationship between moderate intestinal epithelial metaplasia and gastric cancer. Small intestinal type metaplasia with good epithelial differentiation can be seen in various benign gastric diseases, most commonly chronic gastritis, and large intestinal type metaplasia with poor epithelial differentiation and high detection rate in gastric cancer is related to gastric cancer, which needs to be closely monitored, and gastroscopy can be performed once every six months to observe changes in the condition.
Removing the cause is the best strategy to treat and prevent intestinalization, to eat regularly, to quit smoking and drinking, to reduce psychological stress, and to try not to use drugs that are irritating to the stomach. The treatment should be applied to protect the gastric mucosa and eliminate the factors that damage the gastric mucosa. Intestinalization can be further classified into large intestine and small intestine, and large intestine has a higher chance of cancer. Those with moderate intestinalization need regular review and further treatment for other abnormalities.