The wall of the gallbladder is usually not smooth due to diseases such as cholecystitis, which may cause nausea, vomiting, abdominal pain and other symptoms. After the occurrence of cholecystitis, due to the local inflammatory reaction of the gallbladder, the wall of the gallbladder may become congested and edematous, which will be shown as roughness, irregularity and thickening of the wall of the gallbladder in the abdominal ultrasound. In addition, gallbladder polyps and gallbladder cancer and other diseases can also appear in the gallbladder wall is not smooth performance, need to consult a doctor in time to clarify the diagnosis. Gallbladder stones and cholecystitis can cause the wall of the gallbladder to become less smooth, and the main clinical symptoms include nausea, vomiting, right upper abdominal pain and back discomfort. Gallbladder polyps usually have no obvious symptoms, but may also present with upper abdominal pain, nausea and vomiting. Gallbladder cancer may present with clinical symptoms such as right upper abdominal mass, pain and discomfort, and progressive jaundice. If the wall of gallbladder is not smooth, you should consult a doctor in time and take standardized treatment under the guidance of a specialist to help relieve the discomfort as soon as possible.