The appearance of blue blood vessels in the palm of the hand may be a normal physiological phenomenon, but also considered to be superficial venous dilatation, capillary dilatation and other pathological factors, as well as drug factors. 1. Physiological phenomenon: related to the individual’s physique, for the subcutaneous fat is thin, fair-skinned people, you can see through the skin and subcutaneous tissues of the palm of the blue blood vessels are very obvious. In addition, when the palm of the local pressure, resulting in local blood circulation obstacles, this phenomenon may also occur, in the release of local pressure, the symptoms can be gradually relieved, generally without special treatment. 2. Pathological factors: when there is venous thrombosis or venous reflux obstruction caused by other diseases, the patient may have the phenomenon of blue blood vessels in the palm of the hand. At this time, the affected limbs should be elevated, and at the same time the application of heparin, aspirin and other drugs, in addition, long-term exposure to anoxic environment or excessive sun exposure, etc., may induce the expansion of the capillaries to appear in the palms of the symptoms of cyanotic blood vessels. 3. Drugs: Clinical drugs containing hormones, such as dinexed cream, tretinoin econazole cream, etc., after long-term application, it will make the local skin thinning, capillary expansion, can appear palms show the phenomenon of blue blood vessels is very obvious, after stopping the use of medication, the symptom can be gradually improved. Patients with cyanotic blood vessels in the palm of the hand are advised to go to the hospital in time for consultation, after clarifying the cause of the disease, according to the doctor’s advice on the rational use of medication and standardized treatment.