Drinking alcohol after taking Azithromycin is usually not advocated, although Azithromycin unlike and β-lactams can react strongly chemically with alcohol, called disulfiram-like reaction of allergic reactions, but also after taking Azithromycin needs to be closely observed for clinical signs of drug allergy or adverse drug reactions. Close observation is also needed after taking azithromycin, and if clinical manifestations such as itching and rash of the skin appear, you need to go to the hospital immediately. There are also some patients who have certain allergic reactions to certain undesirable ingredients in azithromycin. At this time, such as after drinking alcohol will aggravate such adverse reactions, such as nausea, vomiting, gastrointestinal irritation, abdominal pain, diarrhea and other clinical manifestations, also after drinking alcohol, the symptoms will be significantly aggravated, at this time also need to go to the hospital, drinking alcohol after taking azithromycin need to closely observe the patient’s situation for three days.