After taking azithromycin, it is generally recommended that alcohol be consumed only after 72 hours of taking the drug. Although azithromycin is not like cephalosporin antibiotics which can easily produce disulfiram reaction with alcohol, drinking alcohol can also have some effects on drug metabolism. First of all, drinking alcohol is more damaging to the liver, as most of the drugs are detoxified by the liver, so if you drink alcohol after taking the drug, it is easy to cause damage to the liver, which is very bad for the body and very unfavorable for the recovery of the disease. Secondly, drinking alcohol has a certain damage to the mucous membrane of gastrointestinal tract, and azithromycin also has a certain damage to the mucous membrane of gastrointestinal tract, if you drink alcohol after taking azithromycin, gastritis, gastric ulcer or gastric bleeding will easily occur, and patients will feel nausea, vomiting, abdominal distension or vomit blood, which is very dangerous. So azithromycin is generally safer to drink alcohol after 72 hours of taking it.