Self-harming tendency is more prominent in clinical depression. Antidepressant drugs can be applied to systematic and standardized treatment, such as the application of paroxetine, sertraline, fluoxetine and other drugs, the whole course of systematic and standardized treatment. If the patient’s self-harming and self-injurious behavior is more serious, physical therapy, such as electroconvulsive therapy, can also be applied. Convulsion-free electroconvulsive therapy is effective in treating depression, self-injury, self-mutilation, severe food refusal and defiance. After about 1 course of treatment, 10 times of convulsion-free electroconvulsive therapy, the patient’s self-injurious symptoms can be significantly improved. After the symptoms have subsided, the drug treatment should still be maintained, talking about the whole course of systematic and standardized treatment, and when the symptoms are completely recovered, under the guidance of the doctor, the dosage can be gradually reduced until stopping the drug.