Patients with advanced cancer may show pain, wasting and difficulty in breathing before they go. 1. Pain: Patients with advanced cancer have already developed systemic metastasis, and may have pain in all parts of the body, and the pain is unbearable. 2. Wasting: Due to the erosion of the body by cancer cells, the patient may be in a trance, unable to eat and drink, and have serious skin and bones. Moreover, patients with advanced stage of cancer may also suffer from anorexia. 3. Difficulty in breathing: Patients with advanced cancer are usually already very weak before they go, and may also suffer from extreme malnutrition anemia and low blood pressure. So it leads to weakness of respiratory muscles and symptoms such as dyspnea, breath-holding and increased heart rate. 4. Fluid accumulation in body cavity: advanced tumor metastasizes and spreads to thoracic cavity, abdominal cavity or pelvic cavity, which obstructs the discharge of body fluids and may form a large amount of fluid accumulation. At the same time, the growth of cancer consumes a large amount of albumin in the body, leading to the decrease of plasma osmotic pressure, and the water in plasma flows into the body cavity, and the fluid can be accumulated in the body cavity; 5. Coma: when the cancer is in advanced stage, the cancer may spread to the whole body and invade the nervous system, resulting in neurological symptoms such as drowsiness, dementia, etc., and in serious cases, coma or even shock may occur. Different patients with advanced cancer will have different manifestations before they go, for example, lung cancer patients may manifest hemoptysis, shortness of breath, wheezing, etc. Liver cancer patients may manifest jaundice, liver ascites and other symptoms. When the above symptoms appear, family members need to pay attention to them, and can alleviate the patient’s pain and other symptoms under the guidance of doctors, and need to accompany the patient more.