HLA-DRB1 is a gene, belonging to HLA class II gene, which is mainly distributed on the surface of antigen-presenting cells such as macrophages, dendritic cells, B cells, activated T cells, etc., and participates in the process of antigen presentation, and it is mainly related to the pathogenesis of rheumatoid arthritis, systemic lupus erythematosus and other diseases.
1. Rheumatoid arthritis: it is a systemic, chronic autoimmune disease with erosive, symmetric polyarthritis as its clinical manifestation. Its pathogenesis is highly related to the activation of immune-related cells induced by HLA-DRB1-binding antigenic peptide.
2. Systemic lupus erythematosus (SLE): HLA-DRB1 gene mediates the immune response in SLE.
HLA-DRB1 has a certain correlation with the above two diseases, in addition to leukemia, spondyloarthritis and other immune diseases. In case of abnormal clinical findings, it is recommended to consult a doctor and standardize the diagnosis and treatment under the guidance of a specialist.