Thyroid hormone elevation after taking amiodarone needs to be divided into circumstances, if the patient’s previous thyroid function is normal and the condition allows to consider replacing the drug or stopping treatment, if the condition does not allow to stop the drug can be used to replace the treatment of levothyroxine sodium tablets. Amiodarone belongs to the anti-arrhythmic drugs, can prolong the effective duration of the myocardial tissue and action potential, eliminate the refractory excitation, can be used to treat ventricular, atrial arrhythmia, nodal arrhythmia, arrhythmia with preexcitation syndrome and other diseases. Adverse reactions such as hyperthyroidism, hypothyroidism, nausea, vomiting, and facial flushing may occur after administration. Hypothyroidism due to an adverse drug reaction is usually considered when elevated thyroid-stimulating hormone occurs after taking amiodarone. If the condition allows, can be under the guidance of the doctor to stop treatment, or replace other drugs, generally stop the drug after the patient’s thyroid function can be self-recovery; if the condition does not allow to stop the drug can be used to replace the treatment of levothyroxine sodium tablets. When taking amiodarone, it is recommended to go to the hospital and ask the doctor to make a judgment when the thyroid stimulating hormone rises.