1.Progressively worsening difficulty in eating. 2.Progressive wasting of unknown origin. 3.Prolonged untreated gastric ulcer or superficial ulcer. 4.Irregular vaginal bleeding. 5.Change in stool habit: blood in stool, diarrhea, constipation, etc. 6.Progressive worsening of anemia. 7.Progressively worsening nasal congestion and headache. 8. Painless and progressive enlargement of lymph nodes. 9.Cough, chest pain and hemoptysis that are untreated and progressively aggravated. 10.Significant thickening and enlargement of nevus or superficial tumor in a short period of time.