The clinical staging of hepatic encephalopathy includes 5 stages, including latent stage, prodromal stage, pre-coma, lethargy and coma, which are mainly characterized by different severity of clinical manifestations. 1. Latent stage (stage 0): there are mostly no abnormal changes in behavior and personality, and the EEG examination is normal, and only psychological or intelligence tests will show slight abnormal changes. 2. Prodromal stage (stage 1): There may be mild personality or mental abnormalities such as euphoria or indifference, and there may be mild fluttering tremor, but the EEG is still basically normal. 3. Pre-comatose stage (stage 2): there may be drowsiness, slurred speech, dysgraphia and behavioral abnormalities such as disheveled clothing and urination and defecation, as well as fluttering tremor and hypertonicity and tendon reflexes, and at this time, the electroencephalogram starts to have abnormalities. 4. Coma stage (stage 3): the performance is lethargic, but can be awakened and respond, often with hallucinations, confusion, etc., with fluttering tremor, aggravation of neurological signs, at the same time, there will be Babinski’s sign and other positive signs of the pyramidal fasciculus, and the electroencephalogram will also be abnormal. 5. Coma stage (stage 4): the patient is unconscious and cannot be awakened, so it is difficult to induce fluttering tremor; tendon reflexes and muscle tone are hyperactive in shallow coma, but will be weakened or even disappeared in deep coma. Generally speaking, the symptoms of hepatic encephalopathy can be reversed in the early stage, but it is difficult to be reversed in the late stage, and may even be life-threatening. Therefore, patients with suspected hepatic encephalopathy should consult the doctor in time, and follow the doctor’s instructions for further examination and treatment.