One of the characteristics of severe schizophrenia is that patients do not have “self-awareness,” i.e., they do not acknowledge their illness, refuse to seek medical care, and refuse to take medication or receive other treatment. The survey found that most psychiatric patients take medication passively or “actively” in the hospital; once they are “cured” and return home, the supervision of medication taking is significantly reduced, and patients repeatedly hide medication or take it under false pretenses, which is part of the reason for the recurrence of mental illness and difficulty in controlling it. This is part of the reason why mental illness is recurrent and difficult to control; there are also a few patients, even if they take a sufficient amount of medication, the treatment effect is not ideal, there are still hallucinations, delusions, violent attacks and other abnormal behavior. If the patient’s psychiatric symptoms are not effectively controlled, the consequences can be very serious. For example, the case of a 9-year-old boy who was beaten to death by a man in Changsha is a typical tragedy caused by a sudden psychotic episode. The man had a history of schizophrenia and was discharged from the hospital 2 years later when his family took him off his medication, which eventually led to the tragic consequences. Therefore, the daily decisions of guardians are closely related to the outcome and prognosis of severe schizophrenia. Experts from the Department of Functional Neurology at Shanghai Oriental Hospital believe that for patients with refractory schizophrenia, guardians should not just let the patient take medication because it is unsatisfactory or refuse to take it, or just keep taking mandatory treatment, which often leads to a “treatment improvement” and “relapse This often leads to a circle of “improvement” and “relapse”. The study concluded that guardians should opt for minimally invasive surgical treatment when necessary, which may be a salvage measure for their persistent disease. A minority of guardians will show hesitation when faced with surgical treatment because they do not know about this procedure, which has a lot to do with asymmetric medical information. Most guardians, for all intents and purposes, do not know that surgery can treat psychiatric disorders, let alone understand the mechanisms of treatment. Even if the patient’s condition is already very serious, the family does not know where to look for surgical treatment. The reasons for this situation are manifold and are closely related to the fact that many guardians do not have a good understanding of the overall treatment principles for schizophrenia. 3. There are strict conditions for seriously ill patients to receive surgical treatment. First, the patient has indications for surgery; second, his or her physical condition allows for no major physical illness; and, the guardian agrees to surgical treatment. In conclusion, as long as the guardian chooses the right treatment method and strengthens daily supervision and health counseling, patients with mental illness will definitely obtain a better outcome and prognosis.