Patients with enlarged lymph nodes in the left supraclavicular fossa may be caused by acute cellulitis, left lymphadenitis, left lymphoma, etc. Patients can be relieved by medication, surgery, radiotherapy and so on. 1. Acute cellulitis: For patients with left supraclavicular fossa lymph node enlargement caused by acute cellulitis, topical medications such as magnesium sulfate, mupirocin ointment, etc., can be used under doctor’s guidance; gold plaster, ichthyolite cream, etc., can also be taken as prescribed by the doctor, such as cephalexin, erythromycin and other systemic treatments, and in case of abscess formation, it can be treated by surgical incision and drainage, so as to improve the situation of lymph node enlargement. The left lymph node can also be treated systematically with cefixime and erythromycin. 2. Left-sided lymphadenitis: patients with lymphadenitis can be treated with antibiotics such as cefadroxil, roxithromycin, etc.; antipyretic and analgesic drugs such as ketoprofen gel, ibuprofen, etc. or antiviral drugs such as ganciclovir, adenosine monophosphate, etc. under the guidance of the doctor. For the effect of conservative treatment is not obvious, or progress to lymph node abscess, can try to puncture suction pus, and then incision and drainage treatment. 3. Left-sided lymphoma: lymphoma patients can use immunomodulators, such as cidabenamide, ibrutinib and so on, under the guidance of doctors for treatment. For patients whose drug treatment effect is not obvious, they can also be treated by surgery, radiotherapy and so on, to alleviate the condition. It is recommended that patients strictly follow the doctor’s instructions to use medication, actively cooperate with the doctor’s treatment, pay attention to rest in life, with a light diet, and at the same time do a good job of monitoring the condition, if there is any abnormality, consult a doctor in a timely manner.