The cause of numbness of hands and feet may be peripheral neuritis caused by diabetes, alcoholism caused by long-term drinking, cerebrovascular lesions, Guillain-Barré syndrome, etc., which should be treated with medicines such as insulin and methylcobalamin according to the cause. 1. Diabetes mellitus: Diabetes mellitus can lead to peripheral neuritis, which leads to numbness of the hands and feet, and can be treated by using medicines such as methylcobalamin, vitamin B1 and other nutritive nerves; insulin, metformin and other medicines for lowering blood sugar. 2. Alcoholism caused by long-term alcohol consumption: alcohol causes peripheral neuropathy and numbness of hands and feet. It can be treated by using glutamine, vitamin B, and gradual abstinence from alcohol. 3. Cerebrovascular lesions: cerebrovascular lesions such as cerebral vascular sclerosis, cerebral infarction can also lead to numbness of the hands and feet, and can be treated with antiplatelet drugs such as aspirin, clopidogrel, etc.; lipid-lowering drugs such as simvastatin, atorvastatin, etc.; and blood pressure-lowering drugs such as enalapril, valacyclovir and other drugs. Patients with numbness of the hands and feet, it is recommended to seek medical treatment in a timely manner, specific drugs should be used under the guidance of a doctor, not blindly self-medication.