Milrinone belongs to the phosphodiesterase inhibitors, Milrinone inhibits phosphodiesterase will lead to the elevation of intracellular calcium ions, the contraction force of the heart muscle will be enhanced, it is a kind of cardiac drug. It is a kind of drug applied to heart failure, especially in severe heart failure, middle and advanced heart failure patients with severe dyspnea and edema, the application of milrinone is able to quickly relieve dyspnea and edema. If long-term application of milrinone, it is easy to lead to sudden death, milrinone has the effect of cardiotonic, vasodilatation, milrinone has the effect of lowering blood pressure, the application of milrinone should monitor blood pressure. Milrinone is an intravenous drip drug, contraindications to the application of Milrinone are mainly hypotension, and the application of Milrinone is not recommended for patients with severe hypotension.