The areas where the stomach and intestines are connected are the gastric sinus, pylorus, and duodenum. The pain often felt in this area may be due to pyloritis, duodenal ulcer, and pyloric obstruction. It is necessary to promptly consult the gastroenterology department and take symptomatic medication or surgery after clarifying the specific cause. 1. pyloritis or pyloric ulcer: it may lead to pain in the gastrointestinal junction with vomiting, nausea and other symptoms. It is recommended that the treatment is based on acid suppression and stomach protection, commonly used drugs such as rabeprazole enteric capsules, chewable magnesium aluminum carbonate tablets, etc.; 2, duodenal ulcer: patients due to excessive secretion of gastric acid, resulting in duodenal ulcer, accompanied by gastrointestinal junction pain symptoms. It can be treated with omeprazole, pantoprazole, lansoprazole, rabeprazole, esomeprazole, eprazole, etc.; 3. Pyloric obstruction: pyloric obstruction in the pyloric part of the stomach due to ulcer or cancer and other lesions, accompanied by belching, regurgitation, and pain in the gastrointestinal junction. When the symptoms of pyloric obstruction are obvious, it is necessary to abstain from diet, gastrointestinal decompression, acid suppression and fluid replacement therapy; if necessary, surgical treatment can be taken; 4. Other abdominal diseases: abdominal lymphadenitis or vascular lesions may also cause pain in the gastrointestinal junction. It is recommended to seek medical attention in time to identify the cause and treat it symptomatically. In daily life, patients should pay attention to avoid irritating vegetables, such as leeks, celery and onions, and avoid the intake of thick broth, coffee and fried foods. The diet should be easy to digest, such as porridge and noodles in soup.