The liver plays a huge role in regulating blood glucose metabolism in the body. The liver is equivalent to the body’s chemical factory. When blood sugar is high, the body takes the excess glucose and stores it in the liver in the form of liver glycogen. When blood sugar drops, the liver in turn releases hepatic glycogen into the blood to keep the blood sugar concentration stable. The liver can also maintain blood glucose concentrations through the action of gluconeogenesis. Gluconeogenesis is the process of converting many non-sugar substances in the body, into glucose and glycogen. The liver’s capacity for gluconeogenesis is 10 times greater than the kidney’s capacity for gluconeogenesis. Under starvation, gluconeogenesis is enhanced and the liver converts lactate, pyruvate, amino acids and glycerol into glucose and glycogen through a series of chemical equilibrium reactions to keep the body’s blood glucose level in a normal state. The important role of gluconeogenesis is to maintain the normal blood glucose concentration in the body, especially when the source of glucose in the body is insufficient, using the conversion of non-sugar substances to ensure the relative stability of blood glucose. The normal fasting blood glucose range is 3.9-6.1 mmol/L and 2 hours after meal is 4.4-7.8 mmol/L. The body regulates blood glucose through the liver to maintain it in a relatively stable state. Therefore, if liver diseases occur, such as hepatitis, cirrhosis, or liver cancer, the regulation of blood sugar will be affected, resulting in abnormal glucose tolerance and hypoglycemia.