Hypoechoic intrahepatic areas with poorly defined borders and no blood flow signal may indicate benign liver diseases such as liver abscesses and hepatic adenomas, but do not exclude the possibility of malignant tumors. Liver ultrasound shows intrahepatic hypoechoic areas indicating the presence of areas of lower than normal hepatic echogenicity, and the absence of blood flow signal usually suggests that the area of the lesion may be benign, such as liver abscess, hepatic hemangioma, focal nodular hyperplasia of the liver, hepatic adenoma, and inflammatory pseudotumor. The absence of blood flow signal usually means that no obvious blood vessels are found, which can be interpreted as there is no blood vessel supplying nutrients in the lesion area, and this situation is considered to be more likely to be benign, but smaller malignant tumors can also have no blood supply, therefore, relevant examinations should be done under the guidance of the doctor, such as CT enhancement, nuclear magnetic resonance, ultrasonography, and ultrasound-guided puncture biopsy of the lesion area may be required if necessary. The detection of intrahepatic hypoechoic border is not clear and no blood flow signal, it is recommended that the patient should follow the doctor’s instructions to carry out further examination, to clarify the cause of the disease, and timely treatment.