Whether or not a newborn 22-day cold and fever is dangerous can not be generalized, according to the newborn’s physical condition to determine the newborn’s body, the newborn’s body has no abnormalities, the common cold and fever is generally not dangerous; newborns accompanied by other underlying diseases, cold and fever may be more dangerous. Newborns with 22-day colds commonly have viral infections or bacterial infections. Common colds are self-limiting illnesses, and newborns with normal development since birth have a better prognosis and a lower risk of timely treatment. Newborns 22 days accompanied by underlying diseases, such as neonatal jaundice, neonatal pneumonia, neonatal sepsis, neonatal septic meningitis, immune deficiency, etc., the cold and fever may lead to more serious complications, if not treated in time, will aggravate the degree of these underlying diseases, which may lead to serious consequences. Newborns with 22-day cold and fever should seek medical attention in a timely manner, under the guidance of the doctor to carry out active treatment, to avoid delaying the treatment time.