Severe mitral regurgitation does not heal itself. Severe mitral regurgitation is caused by irreversible lesions of the mitral valve leaflets, annulus, and tendon cords, resulting in mitral valve closure insufficiency. Patients often have reduced cardiac output, which manifests as fatigue and decreased activity tolerance, and pulmonary stasis, resulting in varying degrees of dyspnea, and in the later stages of the disease, symptoms of right heart failure, such as bloating, lack of appetite, and edema, occur. Untreated severe mitral regurgitation can be life-threatening due to severe heart failure, and the progression to heart failure is often rapid. The most common treatments for severe mitral regurgitation are mitral valve repair and mitral valve replacement, and prompt surgical intervention can significantly improve symptoms and quality of life. Patients with severe mitral regurgitation should seek timely hospitalization and early treatment to avoid further progression of the condition.