Adults with a fever of 39 degrees, if oral antipyretics and the use of antipyretic suppositories are ineffective, you need to consider the treatment of antipyretic injections, but also need to identify the cause of the disease. Adults with a fever of 39 degrees can first use antipyretic drugs (such as ibuprofen, acetaminophen, etc.), or the use of antipyretic suppositories (such as acetaminophen suppositories, etc.), which are suppositories used for antipyretic, analgesic and anti-inflammatory. We also need to find out the cause of fever, most of them are bacterial infections, mycoplasma or viral infections, you can take oral antibiotics (such as cefixime, roxithromycin, etc.), and antiviral drugs (such as ribavirin, acyclovir, etc.) treatment. If the fever does not go down with the above treatments, then an antipyretic injection or intravenous fluids should be considered. It is recommended that the patient consult a doctor in a timely manner to identify the cause of the disease and follow the doctor’s instructions to standardize the treatment, do not blindly self-medication.