Possible causes of small holes on the soles of the feet include fossa keratolysis, diabetic foot, leprosy plantar ulcers and so on. 1. Fossa keratolysis: this disease is mostly caused by Coccidioides immitis, and other pathogenic bacteria include Corynebacterium, Congo dermatophilus and Actinomyces, etc. It manifests itself as sweaty feet, bad odor, a little pit on the bottom of the foot, which can be fused into a large piece, roughness, and vesiculobullous surface, and other symptoms. 2. Diabetic foot: poor glycemic control, the body is at a high sugar level for a long time, and high blood sugar can cause damage to the nerves and blood vessels. Symptoms include dry skin, no sweat, hyperpigmentation, surface ulcers, slight pain, dull sensation and resting pain in the foot. 3. Leprosy plantar ulcers:This disease is caused by leprosy, which is a chronic infectious disease caused by Mycobacterium leprae. Usually with the development of the disease, leprosy patients can appear peripheral nerve involvement, in addition to superficial sensory deficits, but also produce movement disorders and deformities, plantar ulcers can appear. It is recommended that patients combine their own situation, timely to the regular hospital dermatology consultation, follow the doctor’s instructions to clarify the diagnosis, reasonable treatment.