Antithyroglobulin antibody of 700IU/ml is out of the normal range, but whether it is serious or not should be combined with the thyroid function, the presence of obvious clinical manifestations, the presence of thyroid parenchymal changes and so on, to further determine the severity of the disease, as follows: 1. Clinical manifestations: Antithyroglobulin antibodies exceeding the normal range by several times may suggest that the patient has toxic diffuse goiter, which will affect the function of multiple systems, such as the emergence of protruding eyes, accelerated heart rate, excessive sweating, hyper-emotional, emaciation, hand tremors and other uncomfortable symptoms, which will seriously affect the patient’s quality of life or cause a life-threatening condition, which is more serious. 2. Thyroid parenchymal changes: when thyroid tumor is present, anti-thyroglobulin antibody may also be significantly elevated. Benign tumors may compress the blood vessels of the surrounding tissues, resulting in discomfort such as dyspnea; if the tumor is malignant, it may also invade the surrounding lymph nodes, with the risk of metastasis. When the above symptoms occur, or the anti-thyroglobulin antibodies continue to rise, it is recommended to consult a doctor in time to identify the cause of the disease and carry out symptomatic treatment.