Chemotherapy is firstly considered for advanced pancreatic cancer, and treatments such as targeting and immunization can be considered after progression. Advanced pancreatic cancer is clinically incurable and inoperable. Compared with other treatments, the probability of chemotherapy sensitivity is relatively high, so chemotherapy is the first choice of treatment. After controlling the disease for a period of time, chemotherapy will produce drug resistance and disease progression, and other treatment means should be changed in time. Targeted therapy is mainly anti-vascular related drugs, which are often used in combination with chemotherapy, and it is important to pay attention to the emergence of bleeding, hypertension and other adverse reactions. Immunotherapy is effective for some patients who are not sensitive to chemotherapy, which can further improve the prognosis and prolong the survival period.