A positive or negative syphilis test can indicate different states of infection and needs to be judged by the results of specific programs. There are two main syphilis tests: (1) non-syphilis spirochete test: used for initial syphilis screening, relatively low cost, easy to carry out, and can be quantified to track the response to treatment. The non-syphilis spirochete test is more specific and remains positive for life once infected, so it cannot be used to observe the effectiveness of treatment, identify relapse or reinfection, etc. If the non-syphilis spirochete test result is positive, the test will not be used. If the non-syphilis spirochete test result is positive, the syphilis spirochete test result is negative, suggesting that it is generally false-positive, commonly found in pregnancy, autoimmune diseases, chronic liver disease and other patients. If the non-syphilis spirochete test result is negative and the syphilis spirochete test result is positive, there are two possible scenarios. One is a previous syphilis infection that has now been cured; the other is a very early infection that resulted in a negative syphilis spirochete test because the relevant antibodies have not yet been produced. In either case, patients are advised to visit a hospital for further examination and treatment under the guidance of a doctor.