Levofloxacin hydrochloride and cephalosporin are antibacterial drugs commonly used in the clinical treatment of infectious diseases, the two are different from the following five aspects of comparison: 1, the concept of different scope: Levofloxacin hydrochloride is an antibacterial drug, cephalosporin is a class of antibacterial drugs, including cephalosporin generation, two generations, three generations and four generations; 2, different production methods: Levofloxacin hydrochloride is an antibacterial drug synthesized through chemical methods, while cephalosporins are mostly extracted from microorganisms and then synthesized. And most of the cephalosporins are extracted from microorganisms and then synthesized, also called antibiotics; 3, different mechanisms of action: levofloxacin mainly acts on the nucleus of bacteria to kill bacteria by inhibiting the replication of DNA, while cephalosporins only act on the cell wall of bacteria to dissolve the cell contents; 4, different antibacterial spectrum: levofloxacin is effective against bacteria, and has antibacterial effects on atypical pathogens such as mycoplasma and chlamydia. It also has antibacterial effect, while cephalosporin is only effective for bacteria; 5. Different contraindicated groups: levofloxacin has an effect on the cartilage development of young animals and is prohibited for patients under 18 years old, while cephalosporin is relatively safe and does not have the above contraindications.