Phenobarbital has a beneficial effect on the gastrointestinal tract by relieving intestinal smooth muscle spasms. Suffering from gastrointestinal diseases, taking phenobarbital can reduce the central nervous system response, relieve intestinal smooth muscle spasm, reduce gastrointestinal discomfort such as diarrhea, convulsions and so on. It can play a supplementary effect on the condition, and other medications should be taken orally as prescribed by the doctor at a later stage, including gastric stimulants, such as domperidone tablets; gastric mucosal protection drugs, such as aluminum thioglycollate, and so on. Phenobarbital is easy to cause rash, wheezing, dyspnea and other symptoms, the treatment will gradually reduce after discontinuation; patients with a history of allergy to phenobarbital, as well as hepatic and renal insufficiency need to be prohibited, pregnant women and lactating women are prohibited. The use of drugs need to be carried out under the guidance of a doctor, the emergence of adverse drug reactions to consult a doctor in time to avoid the development of the disease.