Urine protein is higher after kidney puncture, considering that it is related to the activity or aggravation of the primary disease, usually kidney puncture will not cause higher urine protein. Renal puncture is a test method used for kidney disease, not a treatment method, with a certain degree of trauma. Renal puncture is an irreplaceable test for kidney patients, such as proteinuria, hematuria, renal insufficiency of unknown cause and other patients, clinical often recommended to carry out renal puncture, to clarify the type of pathology, to guide the treatment. Renal puncture is only a means of examination, not a treatment. Urinary protein will still persist after renal puncture and may continue to rise if no intervention is made. Bleeding, oliguria or anuria, hypotension and other side effects may occur after renal puncture, but a small amount of bleeding, which may only be manifested as positive urinary occult blood, or even hematuria of the naked eye, pay attention to rest, stop the bleeding symptomatic disposal, generally can be returned to normal. Patients with higher urine protein after kidney puncture should go to the regular hospital in time and follow the doctor’s advice to take further treatment.