The treatment of cranial defect is to perform cranial repair and molding, but the timing, method and materials used as well as the indications and contraindications of the surgery must be carefully considered, especially the purpose of the patient’s request for repairing the cranial defect. Indications for cranial defect repair: 1.The diameter of cranial defect is greater than 3cm. 2.Aesthetics of the defect site. 3.It causes long-term dizziness, headache and other symptoms that are difficult to relieve. 4.Serious mental burden affecting work and life. Cranial repair is a common surgery, the implementation of which is not difficult and can be carried out in large hospitals in general, as long as the scalp is cut, the periosteum is bluntly separated, the bone window is completely exposed, the repair prosthesis is placed in the bone window and adjusted to achieve physiological anatomical reset, and the skin is sutured layer by layer. Only the surgical approach taken is different, and the results achieved are very different. Some repair materials can also cause side effects after the repair, and the most widely used titanium mesh, some patients can have rejection reactions or other side effects after using it, so patients should also choose the repair hospital and materials carefully and conscientiously. Currently, we carry out peek cranioplasty, which can help patients to achieve the dual goals of basic repair and shape shaping. This procedure is an advanced and mature repair technique that has been studied and summarized from hundreds of pathologies and realized 4 technical innovations with rich experience and good results.