The most effective way to remove lipomas from the buttocks is to opt for surgery, especially if it interferes with the patient’s sitting or resting position and daily activities. Surgery can be performed under local anesthesia, or if the tumor is large and local anesthesia is not effective, surgery can be performed under epidural anesthesia and hospitalization is required. During surgery, attention should be paid to the separation of the tumor and the envelope to avoid residuals, because lipomas are prone to recurrence after surgery, especially in obese patients with multiple lesions, and pathological examination is required after surgery. For obese patients, they should pay attention to a low-salt and low-fat diet, and eat more light foods and easily digestible foods, such as coarse-fiber vegetables and fresh fruits, etc. If there is fatty liver that will affect the metabolism of body fat, you should also actively treat the primary disease and do sports and exercise appropriately.