For gallstones, there is no method that can guarantee pain relief within ten minutes. The pain relief effect varies according to the patient’s body type and condition. Patients with gallstones are advised to undergo pain relief treatment under the guidance of a doctor to avoid delaying the condition or causing other adverse reactions due to improper operation. More commonly used pain relief methods are as follows: 1, drug therapy: for patients with acute attacks of gallstones can be under the guidance of a doctor for anti-inflammatory pain treatment, mild pain often oral non-steroidal anti-inflammatory drugs, such as aspirin, for moderate pain can be oral weak opioids, such as codeine, for patients with severe pain can be considered intravenous or intramuscular injection of morphine pain relief. In addition, choleretic drugs, such as ursodeoxycholic acid tablets, can be used as an adjunct to relieve discomfort. However, patients are forbidden to use pain medications privately to avoid complications such as peritonitis or abdominal infection due to forced analgesia that may mask the condition. In addition, antispasmodic and analgesic drugs are used to relieve discomfort before gallstone surgery, such as indomethacin, flurbiprofen ester, scopolamine, etc.; 2. Surgical treatment: For some patients with gallbladder stones combined with acute cholecystitis attack, if the effect is not good after anti-inflammatory treatment, laparoscopic cholecystectomy also needs to be considered; while for some patients with bile duct stones, if fever, chills, abdominal pain, jaundice and other manifestations occur. then ERCP needs to be considered to remove the stones. In addition, endoscopic treatment, percutaneous hepatic puncture biliary drainage, etc., can also help control infection and relieve pain in elderly and frail patients with poor underlying conditions. 3. Other treatments: Chinese medicine, such as pressing the bile and liver acupuncture points or local hot compresses, moxibustion points, and acupuncture, etc., can also have certain auxiliary effects on relieving pain in patients with gallstones. In addition, gallstones may be caused by greasy diet, obesity, hepatitis, liver disease, diabetes and other causes, so daily life should pay attention to three regular meals, moderate daily exercise, drink more water, etc. can also help prevent recurrence.