“I am a hepatitis B carrier, always worried about transmitting the disease to my children, so although I have been married for 2 years, I have been afraid to have children. I’m almost 30 years old and my parents have been urging me to have a baby, so I don’t dare to delay any longer. Is it possible to get pregnant in my case? Will the virus be passed on to the baby? What can I do to avoid passing it on to my baby?” The above is a question from a netizen. Mother-to-child transmission of HBV is a major cause of existing hepatitis B virus (HBV) infection in China. mother-to-child transmission of HBV, i.e., HBsAg-positive mothers transmitting HBV to their offspring, occurs mainly during and after delivery, while vertical transmission (intrauterine infection before delivery) has an infection rate of <3< span="">%, mostly in HBeAg-positive pregnant women. Many people think that mother-to-child transmission of hepatitis B is genetic, but this is actually a misconception. Heredity is an abnormality that already exists in the genes, while mother-to-child transmission of hepatitis B must be a contagious process. Therefore, if a mother with hepatitis B takes regular preventive measures, the vast majority of mother-to-child transmission can be blocked and she can have a healthy baby. The first thing that young women with hepatitis B should do is to get regular checkups and treatment, and never be an ostrich to avoid reality. Some girls have been checked once and the doctor says they are hepatitis B carriers and don’t need treatment, so they never go to the doctor again, “The doctor has said that I don’t need treatment. In fact, this is not true, this doctor’s words only work for six months. It is important to know that even if you are a hepatitis B carrier with normal liver function, you need to review your liver function, HBVDNA, and ultrasound every six months, and if conditions do not allow, at least once a year is a must to know if your condition is entering the active phase and it is time to do antiviral treatment. If you are tested on time and choose the right time for the right antiviral treatment, such as long-acting interferon (preferred for young patients), “major triple-positive” has a 50% certainty of converting to “minor triple-positive” and “minor triple-positive “In some patients, it is even possible to achieve HBsAg negativity and get the “gold medal” for hepatitis B treatment. These results will allow you to get down to business as a mother in the future. Secondly, hepatitis B mothers-to-be should choose the right time to get pregnant and have regular follow-ups during pregnancy. Before a woman with chronic HBV infection plans to become pregnant, it is best to have her liver function evaluated by a specialist. Those with normal liver function can have a normal pregnancy without worrying about the amount of virus; those with abnormal liver function should choose a reasonable antiviral treatment according to their age and liver function: those who are young and not in a hurry to have a pregnancy right away can prefer interferon injection antiviral for 1 year and can only get pregnant 1 year after stopping the drug; those who are older and in a hurry to have a pregnancy can choose oral antiviral drugs (preferably pregnancy class B, high drug resistance gene The pregnancy will be possible after the liver function returns to normal. After pregnancy, chronic HBV-infected patients must regularly review liver function, especially in early and late pregnancy, if the ALT level increases more than twice the normal value (>80U/L), or the bilirubin level increases, you need to consult with the relevant professional physicians, if necessary, hospitalization. Finally, neonatal disposition: within 12 h after birth, the child is given one intramuscular injection of HBIG; at the same time, hepatitis B vaccination is given according to the 3-dose protocol at 0, 1 and 6 months; in the case of premature babies, one intramuscular injection of HBIG is given within 12 h, and another injection is required after an interval of 3-4 weeks; within 24 h of birth, 3-4 weeks, 2-3 months, and Vaccinations were administered within 24 h of birth, 3-4 weeks, 2-3 months, and 6-7 months, respectively, and followed up. If the child is 7-12 months old, hepatitis B serological markers are tested: if HBsAg negative and anti-HBs positive, prevention is successful and there is resistance; if HBsAg negative and anti-HBs negative, prevention is successful, but 3 more doses of hepatitis B vaccine are needed; if HBsAg positive, prevention fails and the child becomes chronically infected. Although HBV infection can be transmitted from mother to child, this process can be interrupted. After taking the above-mentioned regular preventive measures, the protection rate for newborns of HBsAg-positive and HBeAg-negative pregnant women is 98% to 100%, and the protection rate for newborns of pregnant women who are both HBsAg and HBeAg-positive can be 85% to 95%. The rate of blockage is not 100%, and I am not the most risky category?” Still not sure. So for this category of pregnant women with high risk of mother-to-child transmission, should anti-HBV treatment be administered to reduce the rate of mother-to-child transmission? There is still some controversy. Theoretically, oral gestational class B nucleoside analogs for this group of patients in late pregnancy are effective in reducing mother-to-child transmission by almost 100 percent and have a better safety profile. However, there is no clear conclusion on how long the mother needs to continue taking the drug after delivery and whether it will cause fluctuations in the mother’s hepatitis B status after discontinuation, so it has not been clinically promoted. In some cases, such as the first child who failed the standard blockade procedure, the doctor may consider anti-HBV treatment in late pregnancy to reduce the chance of mother-to-child transmission in the second child. In short, a hepatitis B mother should be scientific and wise, and learn to seek professional help, so you can have a healthy baby just like everyone else.