Hashimoto’s disease does not necessarily progress to hypothyroidism, and there is no cause-specific treatment for the elevated antibody stage, except that limiting iodine intake will help stop the progression of autoimmune destruction of the thyroid gland. In recent years, research has found that selenium yeast tablets may have some effect on the improvement of antibodies, but the medication should not be taken for too long, and it only plays a supplementary role. The key is still to control the intake of iodine, regular examination of the five items of thyroid function, the discovery of subclinical hypothyroidism or hypothyroidism, the timely application of thyroxine tablets for replacement therapy, every 4-6 weeks to check the level of thyroid hormones, adjust the dosage of medication, the emergence of thyroid enlargement is obvious accompanied by pain or symptoms of compression, can be considered to give the treatment of glucocorticosteroid, drug treatment if not relieved should be considered for surgical treatment.