Subpleural grid-like changes in both lungs, i.e., the presence of grid-like hyperdense shadows in both lungs after HRCT (high-resolution CT), are most commonly seen in interstitial pneumonia. Interstitial pneumonia on HRCT is characterized by grid-like lesions, honeycomb changes with or without pulling bronchodilatation, and a predominantly subpleural, basal distribution of the lesions. The clinical manifestations of interstitial pneumonia are active dyspnea with progressive exacerbation, often accompanied by a dry cough. About half of the patients may have a pestle and mortar finger and an audible murmur resembling a nylon buckle (velcro: a type of dry rumbling). The diagnosis of generalized interstitial pneumonia is usually made by a combination of HRCT and surgical lung biopsy pathology. Interstitial pneumonia is incurable, and treatment is aimed at slowing down the progression of the disease, improving quality of life and prolonging survival. If there are corresponding discomfort symptoms, it is recommended to consult a doctor in time, follow the doctor’s advice, and treat the disease as soon as possible.